Systematic review and Meta-analysis of factors influencing taste alterations in cancer patients undergoing chemotherapy
10.3761/j.issn.0254-1769.2025.14.019
- VernacularTitle:癌症化疗患者味觉改变发生率及影响因素的Meta分析
- Author:
Jing LI
1
;
Qiuting MAO
1
;
Yi HUANG
1
;
Fan ZENG
1
;
Mo XIONG
1
;
Qianqian LI
1
;
Shuanghong ZHOU
1
Author Information
1. 430030 武汉市 华中科技大学同济医学院附属同济医院护理部
- Publication Type:Journal Article
- Keywords:
Cancer;
Chemotherapy;
Taste Alterations;
Influencing Factors;
Meta-Analysis;
Evidence-Based Nursing
- From:
Chinese Journal of Nursing
2025;60(14):1778-1785
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the factors affecting taste alteration in patients undergoing cancer chemotherapy.Methods PubMed,Cochrane Library,Web of Science,CINAHL,Embase,CBM,CNKI,WanFang Data and VIP were searched from the establishment until August 1,2024.The retrieved literature was independently screened,evaluated and the data were extracted by 2 researchers,and statistical analysis was performed using Stata 17.0 software.Results A total of 18 studies were included,involving 4 686 patients.The incidence of taste changes is 73.46％.Totally 9 influencing factors were extracted through quantitative analysis,including oral mucositis(OR=1.98),dry mouth(OR=1.82),nausea(OR=3.05),loss of appetite(OR=2.41),use of triple antiemetic drugs(OR=2.45),gynecological cancers(OR=0.67),lung cancer(OR=0.57),paclitaxel types of chemotherapy d rugs(OR=2.86),and smoking(β=9.38).Conclusion The alteration of taste in cancer chemotherapy patients is in-fluenced by multiple factors.Nurses should regularly and dynamically assess changes in taste and implement individualized and refined nursing interventions in clinical practice to prevent or delay the development of taste alterations,thereby improving patients' quality of life and treatment adherence.
