Effect of esketamine on early postoperative mental state in patients with breast cancer
10.3969/j.issn.1673-9701.2025.07.015
- VernacularTitle:艾司氯胺酮对乳腺癌患者术后早期精神状态的影响
- Author:
Xiaolei LIN
1
;
Guangfan MA
1
;
Xiaozhen CHEN
1
;
Sen ZHOU
1
Author Information
1. 温州市中西医结合医院麻醉手术科,浙江温州 325000
- Publication Type:Journal Article
- Keywords:
Esketamine;
Type Ⅱ thoracic nerve block;
Modified radical mastectomy;
Anxiety;
Depression;
Adverse reaction
- From:
China Modern Doctor
2025;63(7):63-66,92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of esketamine on the early mental state of patients after modified radical mastectomy.Methods From August 2022 to September 2024,95 patients with breast cancer who received modified radical mastectomy in Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine were selected and divided into control group(48 cases)and experimental group(47 cases)according to random number table method.Patients in both groups were routinely anesthetised and underwent type Ⅱ thoracic nerve block under ultrasound guidance.The experimental group was given a single intravenous injection of esketamine 0.25mg/kg before incision,while the control group was injected with the same amount of physiological saline.The incidence of adverse reactions,visual analogue scale(VAS)score,brain-derived neurotrophic factor(BDNF),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),Hamilton depression scale(HAMD)score,Hamilton anxiety scale(HAMA)score,functional assessment of cancer therapy-breast(FACT-B)score were all compared between two groups.Results On the 1st and 3rd day after surgery,the levels of TNF-α and IL-1β,the scores of HAMA and HAMD in experimental group were significantly lower than those in control group,and the level of BDNF was significantly higher than that in control group(P＜0.05).The FACT-B score of experimental group was significantly higher than that of control group at the first clinic after surgery(P＜0.05).On the first day after surgery,there were no significant differences in the incidence of nausea,vomiting,hallucination,nightmare,agitation,lethargy and VAS score between two groups(P＞0.05).Conclusion The subanesthetic dose of esketamine combined with type Ⅱ thoracic nerve block can improve the early postoperative mental status of patients undergoing modified radical mastectomy.
