Diagnostic value of nCD64 index,CRP,IL-6 and PCT in viral and bacterial upper respiratory tract infections
10.3969/j.issn.1673-9701.2025.07.011
- VernacularTitle:nCD64指数、CRP、IL-6与PCT在病毒性和细菌性上呼吸道感染中的诊断价值
- Author:
Junliang WU
1
;
Mingli ZHU
;
Qian HUANG
;
Songling LEI
;
Jianghao CHENG
Author Information
1. 浙江中医药大学附属杭州市西溪医院开放实验室,浙江 杭州 310023;浙江大学医学院附属金华医院检验科,浙江金华 321000
- Publication Type:Journal Article
- Keywords:
Neutrophils CD64 index;
C reactive protein;
Interleukin-6;
Procalcitonin;
Bacterial infection;
Viral infection
- From:
China Modern Doctor
2025;63(7):46-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of neutrophils CD64(nCD64)index,C reactive protein(CRP),interleukin-6(IL-6)and procalcitonin(PCT)in viral and bacterial upper respiratory tract infections.Methods Patients with upper respiratory tract infection treated in Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University from January 2023 to January 2024 were selected as study objects.According to the results of etiological examination,they were divided into bacterial infection group(46 cases)and viral infection group(58 cases).The levels of nCD64 index,CRP,IL-6 and PCT before medication were compared between two groups.Receiver operating characteristic(ROC)curve was used to evaluate the value of infection markers in the differential diagnosis of bacterial and viral upper respiratory tract infections.Results The levels of CRP,nCD64 index,IL-6 and PCT in bacterial infection group were significantly higher than those in viral infection group(P＜0.01).ROC curve results showed that the area under the curve(AUC)of nCD64 index,CRP,PCT and IL-6 to distinguish the two types of infection were 0.818,0.776,0.692 and 0.654,respectively,and the combined AUC of four indexes was 0.870.Conclusion nCD64 index,CRP,IL-6 and PCT are closely related to the pathogen types of patients with upper respiratory tract infection,and the combined detection of all indicators can improve the diagnostic efficiency of upper respiratory tract infection types.
