Correlation analysis of white blood cell level and blood cell indexes in megaloblastic anemia patients
10.3969/j.issn.1673-9701.2025.07.010
- VernacularTitle:巨幼细胞贫血患者白细胞水平与血细胞指标的相关性分析
- Author:
Mengjia SUN
1
;
Hangfeng MENG
1
Author Information
1. 杭州艾迪康医学检验中心临床实验室,浙江 杭州 310030
- Publication Type:Journal Article
- Keywords:
White blood cell;
Red blood cell;
Megaloblastic anemia;
Diagnostic value
- From:
China Modern Doctor
2025;63(7):43-45,80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between white blood cell(WBC)and blood cell indexes in megaloblastic anemia(MA)patients.Methods A total of 79 patients diagnosed as MA by bone marrow cell morphology at Adicon Medical Laboratory Center from June 2023 to June 2024 were included in MA group,and another 40 healthy physical examination subjects during the same period were included in health group.The levels of WBC,red blood cell(RBC),platelet(PLT),hemoglobin(Hb)and mean corpuscular hemoglobin(MCH),mean corpuscular volume(MCV)were measured and compared between two groups.Spearman correlation was used to analyze the correlation of each parameter.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of WBC in MA.Results The levels of WBC,PLT,Hb and RBC in MA group were significantly lower than those in healthy group(P＜0.05),MCH and MCV levels were significantly higher than those of healthy group(P＜0.05).WBC was positively correlated with PLT,Hb and RBC(P＜0.05),and were negatively correlated with MCH and MCV(P＜0.05).ROC curve analysis showed that the area under the curve of WBC diagnosis MA was 0.926(95％CI:0.876-0.975).The levels of PLT,Hb and RBC in severe and above group were significantly lower than those in mild to moderate group(P＜0.05).The degree of anemia in MA patients was negatively correlated with the levels of PLT,Hb and RBC(P＜0.05),and the more severe the anemia,the lower the levels of PLT,Hb and RBC.Conclusion The changes of WBC and RBC are related to the occurrence of MA,and WBC can be used as a reference index for the diagnosis of MA.
