A Mendelian randomization analysis of the association between spinal stenosis and constipation
10.3969/j.issn.1673-9701.2025.06.009
- VernacularTitle:椎管狭窄与便秘关系的孟德尔随机化分析
- Author:
Lipeng GUO
1
;
Yanzhi HU
;
Minghan ZHOU
;
Wuji XU
Author Information
1. 湖南中医药大学第二中医临床学院,湖南长沙 410005
- Publication Type:Journal Article
- Keywords:
Spinal stenosis;
Constipation;
Linkage disequilibrium score regression;
Local analysis of variant association;
Two-sample Mendelian randomization
- From:
China Modern Doctor
2025;63(6):45-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the global and loci-specific genetic correlations and bidirectional causal relationships between spinal stenosis(SS)and constipation.Methods Utilizing the publicly available genome-wide association study data from the European population,linkage disequilibrium score regression and local analysis of variant association were used for quantifying genetic correlation at both global(genome-wide)and local(genomic regions)levels,and a two-sample Mendelian randomization(TSMR)analysis was conducted:Four distinct methods,namely the inverse variance weighting method,MR-Egger regression method,weighted median method,and weighted mode,were utilized for analysis and evaluation of the results;Cochran's Q test,leave-one-out method,MR-Egger intercept test,Mendelian randomization polymorphic residuals,and outlier tests were applied to examine the stability and reliability of the results.Results The analysis of linkage disequilibrium score regression and local analysis of variant association revealed that a total of 71 regions had at least one pair of traits with local genetic correlations.The TSMR analysis,with SS as the exposure and constipation as the outcome,based on the results of the inverse variance weighting method,suggested a causal relationship between two(OR=1.077,95％CI:1.034-1.122,P=0.000);Cochran's Q test and MR-Egger intercept test indicated the absence of heterogeneity or pleiotropy,and were verified by the analysis of Mendelian randomization polymorphic residuals,and outlier tests,demonstrating that the results of this study did not exhibit horizontal pleiotropy;The sensitivity analysis using the leave-one-out method indicated that the research results were stable.With constipation as the exposure factor and SS as the outcome,no eligible instrumental variables were found.Conclusion There are significant global and loci-specific genetic correlations between SS and constipation,and SS may be a risk factor for the occurrence of constipation.
