The application value of shear wave elastography in the assessment of non-alcoholic fatty liver disease in children
10.3969/j.issn.1673-9701.2025.07.004
- VernacularTitle:剪切波弹性成像评估儿童非酒精性脂肪性肝病的应用价值
- Author:
Hongfeng WANG
1
;
Guohui LIU
;
Qiong YU
Author Information
1. 内蒙古自治区妇幼保健院超声医学科,内蒙古呼和浩特 010020
- Publication Type:Journal Article
- Keywords:
Shear wave elastography;
Non-alcoholic fatty liver disease;
Evaluation
- From:
China Modern Doctor
2025;63(7):14-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application value of shear wave elastography(SWE)in non-invasive quantitative assessment of non-alcoholic fatty liver disease(NAFLD)in children,and provide diagnostic clues for early clinical intervention in children with NAFLD.Methods A total of 362 children voluntarily examined in Inner Mongolia Maternal and Child Health Hospital from February 2022 to June 2023 were selected as the study objects,and were divided into NAFLD group(216 cases)and control group(146 cases)according to the examination results.The age,sex,body mass index(BMI),alanine aminotransferase(ALT),y-glutamyl transferase(γ-GGT),uric acid,total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),insulin,high density lipoprotein(HDL),glucose,aspartate aminotransferase of two groups of children were collected and compared.Spearman rank correlation was used for correlation analysis.Receiver operating characteristic(ROC)curve was used to determine the predictive value of Young's modulus to NAFLD.Results BMI,liver Young's modulus,portal flow velocity,ALT,y-GGT,uric acid,TC,TG,LDL and insulin in NAFLD group were significantly higher than those in control group,while HDL was significantly lower than that in control group(P＜0.05).Liver Young's modulus was positively correlated with portal flow velocity,BMI,ALT,y-GGT,uric acid,TC,TG,LDL and insulin,and negatively correlated with HDL(P＜0.05).ROC curve results showed that the area under the curve of liver Young's modulus predicted NAFLD in children was 0.873(95％CI:0.836-0.910),sensitivity was 75.0％,specificity was 93.2％.Conclusion SWE can evaluate NAFLD non-invasively,real-time and quantitatively,and provide important clinical diagnostic information for early intervention and treatment of children with NAFLD.
