The real world study of bulleyaconitine A combined with hot package in the treatment of KOA
10.3969/j.issn.1673-9701.2025.06.013
- VernacularTitle:草乌甲素联合热奄包治疗KOA真实世界研究
- Author:
Yuxin YANG
1
;
Dujun MA
;
Yujie BI
;
Yuhao ZHOU
;
Yinxiang WEN
;
Qiuhui ZHONG
Author Information
1. 广州中医药大学第四临床医学院,广东 深圳 518033;深圳市中医院骨伤科,广东 深圳 518033
- Publication Type:Journal Article
- Keywords:
Knee osteoarthritis;
Real world research;
Bulleyaconitine A;
Hot package
- From:
China Modern Doctor
2025;63(6):65-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical efficacy of real-world bulleyaconitine A tablets combined with salt and pepper seven-seed hot package in the treatment of knee osteoarthritis(KOA).Methods 110 outpatient patients from the Department of Orthopedics,Shenzhen Traditional Chinese Medicine Hospital from December 2023 to August 2024 were selected,they were randomly divided into control group of 53 cases and treatment group of 57 cases.The patients in control group were treated with flurbiprofen gel paste,the patients in treatment group received oral administration of bulleyaconitine A tablets and external application of Jiaoyan Qizi hot package,the treatment course were all 4 weeks.All patients were followed up for 2 weeks after the end of treatment.Western Ontario and McMaster University osteoarthritis index(WOMAC)score,Lequesne score,12-item short form health survey(SF-12)score and clinical efficacy were compared between two groups,and adverse events were recorded.Results The total effective rate of treatment group was 87.7％,which was significantly higher than 71.7％of control group(P＜0.05);After treatment,WOMAC score,Lequesne score and SF-12 score in two groups were better than before treatment(P＜0.05).The improvement of WOMAC score,Lequesne score and SF-12 score in treatment group were more obvious(P＜0.05).Conclusion For KOA patients with cold and damp obstruction syndrome,the use of bulleyaconitine A tablets combined with Jiaoyan Qizi hot package can alleviate knee joint pain,improve knee joint mobility,and enhance patients'quality of life.
