Research on medication rules of Chinese medicine in treating chronic kidney disease with spleen and kidney deficiency based on the mutual admiration of spleen and kidney
10.3969/j.issn.1673-9701.2025.06.011
- VernacularTitle:基于脾肾互赞探讨中药治疗脾肾亏虚型慢性肾脏病的用药规律
- Author:
Chenyang PEI
1
;
Guanghui ZHONG
;
Chenchen WANG
;
Yuwei SONG
;
Rongrong ZHANG
;
Qingyun MAO
Author Information
1. 浙江中医药大学第三临床医学院,浙江 杭州 310053
- Publication Type:Journal Article
- Keywords:
Mutual admiration of spleen and kidney;
Spleen and kidney deficiency;
Chronic kidney disease;
Data mining;
Medication rule
- From:
China Modern Doctor
2025;63(6):55-59,64
- CountryChina
- Language:Chinese
-
Abstract:
Objective Based on the theory of mutual admiration of spleen and kidney,this study intends to explore the medication patterns of traditional Chinese medicine for the treatment of spleen-kidney deficiency-type chronic kidney disease(CKD)by using data mining methods and to provide reference for the clinical treatment of spleen-kidney deficiency-type CKD.Methods The literatures included in China National Knowledge Infrastructure,Wanfang Data Knowledge Service Platform,and VIP databases were used as data sources.The literature related to traditional Chinese medicine treatment of spleen-kidney deficiency-type CKD was analyzed by Excel 2021,IBM SPSS Modeler 18.0,IBM SPSS Statistics 27,and systematic clustering analysis and finally visualized by Cytoscape 3.7.2,RStudio.Results A total of 90 prescriptions were included,involving 146 flavors of drugs.The top 5 high-frequency drugs were Huangqi,Fuling,Baizhu,Dahuang,and Danshen.The medicinal properties are mainly mild and warm;The medicinal taste is characterized by sweetness,bitterness,and pungent;The main meridians of drugs are spleen,liver,and kidney meridians.Association rule analysis demonstrated that the commonly used couplet drugs were Huangqi-Fuling and Huangqi-Baizhu;Commonly used corner drugs included Huangqi-Baizhu-Fuling and Huangqi-Dahuang-Fuling.Cluster analysis found that the clustering effect of spleen-kidney deficiency-type CKD treatment drugs in five categories was better.Conclusion The medication rules of traditional Chinese medicine in the treatment of spleen-kidney deficiency-type CKD are preliminarily clarified,which provides a basis for clinical medication and new prescription development.
