Assessment of left ventricular systolic function in patients with systemic lupus erythematosus using aCMQ technique
10.3969/j.issn.1673-9701.2025.05.016
- VernacularTitle:aCMQ技术评价系统性红斑狼疮患者左心室收缩功能
- Author:
Ziran JIN
1
;
Yan LI
1
;
Xuan LIU
1
;
Haotian SUN
1
;
Jing GAO
1
Author Information
1. 锦州医科大学附属第一医院超声医学科,辽宁锦州 121001
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus;
Automatic cardiac motion quantification;
Systemic lupus erythematosus disease activity index;
Left ventricular systolic function
- From:
China Modern Doctor
2025;63(5):57-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of left ventricular(LV)systolic function impairment in patients with different activity levels of systemic lupus erythematosus(SLE)by applying automatic myocardial motion quantification(aCMQ)technique,and to explore the correlation between left ventricular strain parameters and clinical laboratory indexes,systemic lupus erythematosus disease activity index(SLEDAI).Methods A total of 80 patients diagnosed with SLE from November 2023 to August 2024 in the First Afticiated Hospital of Jinzhou Medical University were selected and divided into two groups:40 cases with SLEDAI＜10points were in mild lupus group,34 cases with SLEDAI ≥ 10points were in moderately severe lupus group.Forty healthy volunteers for physical examination at the same time were randomly selected as control group,relevant parameters were obtained by conventional echocardiography and aCMQ technique respectively.Results aCMQ technique related parameters were compared,and the differences in left ventricular global longitudinal strain(LVGLS),apical two-chamber longitudinal strain(AP2LS),apical three-chamber longitudinal strain(AP3LS),and apical four-chamber longitudinal strain(AP4LS)were statistically significant in all three groups(P＜0.05).The differences in left ventricular global circumferential strain(LVGCS)in lupus moderate-severe group were statistically significant when compared with other two groups(P＜0.05),Pearson correlation analysis showed LVGLS,AP2LS,AP3LS,AP4LS and LVGCS were positively correlated with complement 3 and complement 4,and negatively correlated with anticardiolipin antibody(ACA)IgA,IgG,IgM,and sedimentation,and ultrasensitive C-reactive protein,and the SLEDAI was correlated with LVGLS,AP2LS,AP3LS,AP4LS were negatively correlated,and there was no significant correlation with LVGCS.Conclusion aCMQ technique can detect changes in LV systolic function in SLE patients at an early stage,and the impairment of LV systolic function is more severe with higher disease activity.Better correlation between LV strain parameters and clinical laboratory indexes and SLED AI may help to better assess cardiac involvement in SLE patients.
