Causal relationship between vitamin C supplementation and sepsis:Mendelian randomization study
10.3969/j.issn.1673-9701.2025.05.004
- VernacularTitle:维生素C补充和脓毒症关系:孟德尔随机化研究
- Author:
Jinquan LIANG
1
;
Lin LIU
1
;
Min SHAO
1
Author Information
1. 安徽医科大学第一附属医院重症医学科,安徽 合肥 230000
- Publication Type:Journal Article
- Keywords:
Sepsis;
Vitamin C;
Mendelian randomization
- From:
China Modern Doctor
2025;63(5):13-14,31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess on-related association and causality of vitamin C supplementation and sepsis risk by using two-sample Mendelian randomization(MR)design.Methods The study was based on Genome-Wide Association Studies data to screen single nucleotide polymorphisms associated with vitamin C supplementation as instrumental variables.The association of vitamin C supplementation and risk of sepsis was assessed by MR Egger,weighted median,inverse variance weighting,simple model,and weighted model.Results Inverse variance weighting showed a significant negative association between vitamin C supplementation and the risk of sepsis(P=0.030).Sensitivity analysis was consistent with no significant evidence of significant heterogeneity or pleiotropy.Conclusion There is a potential reverse causal relationship between vitamin C supplementation and reduced sepsis risk,and appropriate vitamin C supplementation may provide a feasible intervention for sepsis prevention.
