Expression and prognostic significance of TM7SF2 in colorectal cancer based on bioinformatics analysis
10.3969/j.issn.1673-9701.2025.05.003
- VernacularTitle:基于生物学信息分析TM7SF2在结直肠癌中的表达及预后
- Author:
Ying JIAN
1
;
Zhongqi WANG
;
Zhi ZHANG
;
Xuemei ZHANG
Author Information
1. 华北理工大学公共卫生学院,河北唐山 063210;河北省煤矿卫生与安全重点实验室,河北唐山 063210
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Prognosis;
Immune infiltration;
Drug sensitivity
- From:
China Modern Doctor
2025;63(5):9-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression and prognostic association of transmembrane 7 superfamily member 2(TM7SF2)in colorectal cancer using bioinformatics techniques.Methods The differential expression levels and clinical relevance of TM7SF2 mRNA in normal tissues and colorectal tumor tissues were analyzed using The Cancer Genome Atlas(TCGA)database.Evaluate the impact of TM7SF2 gene expression levels on patient prognosis through univariate and multivariate Cox regression analysis.Gene sets were download and score biological function changes by using the gene set variation analysis algorithm.Patients were divide into high and low expression groups based on TM7SF2 gene expression levels and the differences in signaling pathways with gene set enrichment analysis(GSEA)analyzed;use the CIBERSORT tool to assess the relationship between tumor immune cell infiltration and TM7SF2,apply the genomics of drug sensitivity in cancer(GDSC)database to predict the drug chemosensitivity of this gene,and describe the association between TM7SF2 gene expression and clinical indicators in colorectal cancer patients.Results Compared with normal tissues,the expression level of TM7SF2 in tumor tissues was significantly upregulated.Survival analysis indicates that high expression of the TM7SF2 gene was associated with poor prognosis in colorectal cancer patients.Through univariate and multivariate Cox regression model analysis,it was found that the expression level of TM7SF2 was a risk factor for the prognosis of colorectal cancer.Enrichment analysis suggested that TM7SF2 may play a role in pathways such as DNA replication,Wnt signaling pathway,and pentose phosphate pathway.TM7SF2 was positively correlated with regulatory T cells and CD8+T cells,and negatively correlated with memory CD4+T cells and neutrophils.In terms of drug sensitivity,TM7SF2 is correlated with the sensitivity to Camptothecin,Cisplatin,Docetaxel,Nilotinib,Olaparib,and Axitinib.Regression analysis showed that the contribution of TM7SF2 expression distribution to different clinical indicators varies.Conclusion TM7SF2 is highly expressed in colorectal cancer tissues and is associated with poor patient prognosis,can be used as a prognostic biomarker.
