Mechanisms and research progress of regulatory T cells in tumors
10.12354/j.issn.1000-8179.2025.20250313
- VernacularTitle:调节性T细胞在肿瘤中的作用机制及研究进展
- Author:
Yang XIAOHUI
1
;
Ma FAQIANG
;
Su XIALU
;
Li SHENG
;
Jin FENG
Author Information
1. 贵州医科大学临床医学院肿瘤学教研室(贵阳市 550000)
- Publication Type:Journal Article
- Keywords:
regulatory T cells(Tregs);
tumor;
molecular targeted therapy;
immunotherapy
- From:
Chinese Journal of Clinical Oncology
2025;52(9):465-469
- CountryChina
- Language:Chinese
-
Abstract:
Regulatory T cells(Tregs)are key regulators of the immune system and play important roles intumorigenesis and tumor progres-sion.They exert immunosuppressive effects through immune checkpoint pathways and by secreting inhibitory cytokines and specific chemokines as well as through other mechanisms that promote tumor immune escape.However,their mechanisms of action are complex and involve multistage,multifactorial processes.This article summarizes the mechanisms by which Tregs exert immunosuppressive effects in tumors and promote immune escape and describes related research progress.This study aims to provide a reference for an indepth under-standing of immune regulatory mechanisms in tumors and the development of novel therapeutic strategies.
