Study on the effect of Bian-stone-based herbal heat therapy on gastrointestinal reactions during the precon-ditioning period of hematopoietic stem cell transplantation patients
10.3761/j.issn.0254-1769.2025.12.002
- VernacularTitle:砭石中药热熨在造血干细胞移植患者预处理期胃肠道反应中的应用研究
- Author:
Binlian YAO
1
;
Min XU
;
Xiaopei MAO
;
Min PENG
;
Rui ZHU
;
Xiaolan ZHANG
;
Menghua YE
;
Danhua YANG
Author Information
1. 310006 杭州市 浙江中医药大学附属第一医院(浙江省中医院)护理部
- Publication Type:Journal Article
- Keywords:
Medicinal Ironing Therapy;
Hematopoietic Stem Cell Transplantation;
Gastrointestinal Tract;
Traditional Chinese Medicine Nursing
- From:
Chinese Journal of Nursing
2025;60(12):1420-1426
- CountryChina
- Language:Chinese
-
Abstract:
Objective Exploring the effect of Bian-stone-based herbal heat therapy on herbal heat ironing in gastrointestinal reactions during the preconditioning period of hematopoietic stem cell transplantation patients.Methods Convenience sampling method was used to select 68 cases of hematopoietic stem cell transplantation patients who attended the hematology department of a tertiary-level Chinese medicine hospital in Hangzhou from October 2023 to April 2024 as the study subjects,and the SPSS 26.0 statistical software was used to generate a random number for grouping into an experimental and a control group,with 34 cases in each group.On the basis of intravenous antiemetic medication and routine,the experimental group implemented the Bian-stone-based herbal heat therapy on the basis of intravenous antiemetic medication and conventional nursing care.In the control group,intravenous antiemetic drugs and routine care were used,and the intervention duration of both groups was 14 d,of which 7 d was a course of treatment,with a total of 2 courses of treatment.The incidence of gastroin-testinal reactions,Gastrointestinal Symptom Rating Scale(GSRS)score,Pepsin Ⅰ(PG Ⅰ),Pepsin Ⅱ(PG Ⅱ),and the ratio of PG Ⅰ to PG Ⅱ(PGR)before and after the intervention were compared between the 2 groups.Results The final sample of 66 cases was collected in this study,and 1 patient was dislodged from each of the control group and the experimental group.The comparison of the incidence of gastrointestinal reactions between the 2 groups within 14 days showed that the incidences of nausea,vomiting,abdominal distension,and diarrhea were lower in the experimental group than those in the control group(P＜0.05).GSRS scores on days 1,8,and 14 of intervention were compared,and there were effects between groups in both groups(F=5.338,P=0.017).The levels of PG Ⅰ,PG Ⅱ in the experimental group on day 8 of the intervention were lower than those in the control group.The levels of PGR was higher than that in the control group(all P＜0.05).The safety of the 2 groups after treatment was evaluated,and the results showed that no serious adverse events occurred in the 2 groups.Conclusion Bian-stone-based herbal heat therapy can improve gastrointestinal reactions and reduce the incidence of gastrointestinal reactions during the preconditioning period of hematopoietic stem cell transplantation patients,which provides clinical guidance for the application of Bian-stone-based herbal heat therapy by nursing staff in the future.
