Changes in gut microbiota and clinical significance during radiotherapy in patients with prostate cancer
10.12354/j.issn.1000-8179.2025.20250226
- VernacularTitle:前列腺癌患者放射治疗过程中肠道菌群变化及临床意义
- Author:
Chen XIAN
1
;
Nuerrula YILIYAER
;
Xu MINGYAN
;
Feng RONG
;
Zhao MENG
;
Xiao LEI
Author Information
1. 新疆医科大学第一附属医院肿瘤中心二科(乌鲁木齐市 830000)
- Publication Type:Journal Article
- Keywords:
prostate cancer;
gut microbiota;
radiotherapy;
chronic radiation enteritis
- From:
Chinese Journal of Clinical Oncology
2025;52(9):438-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate how gut microbiota changes during prostate cancer radiotherapy and decipher the relationship of gut microbiota with disease progression and chronic radiation enteritis.Methods:Thirty-one patients with prostate cancer were included in this study,admitted to The First Affiliated Hospital of Xinjiang Medical University from September 2022 to December 2023.The clinical data and stool samples of the patients were collected,and patients were followed up.The collected stool specimens were subjected to 16S rRNA se-quencing to detect gut microbiota and bioinformatics analysis.Results:The relative abundance of phyla such as Firmicutes and Actinobac-teria increased,and that of Bacteroidetes decreased(P<0.05)with an increasing radiotherapeutic dose,while beta diversity was significantly higher(P=0.001).The relative abundance of the phylum Actinobacteria was significantly higher in the prostate cancer progression group than in the non-progression group(P<0.05),the relative abundances of genera such as Sutterella and Haemophilus were significantly higher in the progression group(P<0.05).That of Verrucomicrobia and its offshoots in Akkermansia was higher in the chronic radiation enteritis than in the non-enteritis group(P<0.05),while the relative abundances of Coprococcus_1 and Catabacter in the non-enteritis group were higher than those in the enteritis group(P<0.05).Conclusions:Radiotherapy dose accumulation significantly remodeled the floral structure.Sutterella and Haemophilus of the phylum Proteobacteria might be key flora in prostate cancer recurring early after treatment.An augmen-ted abundance of Akkermansia might increase the risk of chronic radiation enteritis,whereas the flora under the Lachnospiraceae branch might exert aprotective effect against chronic radiation enteritis.
