A study on latent classes and influencing factors of blood glucose trajectories after transplantation in lung transplantation patients
10.3761/j.issn.0254-1769.2025.12.006
- VernacularTitle:肺移植患者移植后血糖变化轨迹的潜在类别及影响因素研究
- Author:
Luyao GUO
1
;
Fei ZENG
1
;
Meijuan LAN
1
;
Lingyun CAI
1
;
Jiangshuyuan LIANG
1
;
Peipei GU
1
;
Yan ZHU
1
Author Information
1. 310000 杭州市 浙江大学医学院附属第二医院护理部
- Publication Type:Journal Article
- Keywords:
Lung Transplantation;
Post-Transplant Diabetes Mellitus;
Latent Class;
Root Cause Analysis;
Longitudinal Studies;
Nursing Care
- From:
Chinese Journal of Nursing
2025;60(12):1447-1453
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the latent classes and influencing factors of blood glucose trajectories after transplantation in lung transplantation patients,and provide references for identifying high-risk population of post-transplant diabetes mellitus.Methods 122 lung transplantation patients who were hospitalized in a tertiary A general hospital in Hangzhou from January 2022 to March 2023 were selected conveniently as survey subjects.Socio-demographic and disease-related data were collected,and fasting plasma glucose at 1 week before surgery(T0),1 week after surgery(T1),1 month after surgery(T2),3 months after surgery(T3),6 months after surgery(T4),1 year after surgery(T5)were collected.Growth mixture model was used to identify categories of blood glucose trajectories after lung transplantation,and binary Logistic regression analysis was used to explore the influencing factors.Results A total of 109 lung transplantation patients were enrolled in the study,and 2 latent classes of blood glucose trajectories were identified:high risk(23.85％)and low risk(76.15％)of post-transplant diabetes mellitus.BMI,drinking history,afternoon blood glucose and tacrolimus trough concentration were the influencing factors of latent classes of blood glucose trajectories after lung transplantation(all P＜0.05).Conclusion There are 2 latent classes of blood glucose trajectories after lung transplantation,namely high risk and low risk of post-transplant diabetes mellitus.Medical staff should pay attention to diabetes screening and assessment of lung transplantation patients who are overweight or obese,have a drinking history before transplantation,have high afternoon blood glucose in early stage of transplantation and have high tacrolimus trough concentration in stable stage of transplantation,so as to formulate a comprehensive and individualized blood glucose management program.
