Analysis of 237 cases of thyroid related adverse drug reaction induced by lithium carbonate
10.3969/j.issn.1673-9701.2025.18.011
- VernacularTitle:237例碳酸锂致甲状腺相关药物不良反应分析
- Author:
Fang WANG
1
;
Li ZHAO
;
Yuru YAN
;
Yupei HAO
;
Yongli LIU
Author Information
1. 河北省药物警戒中心监测评价一部,河北石家庄 050090
- Publication Type:Journal Article
- Keywords:
Lithium carbonate;
Thyroid hormone;
Hypothyroidism;
Goiter enlargement;
Hyperthyroidism;
Adverse drug reaction;
Safety
- From:
China Modern Doctor
2025;63(18):50-53,67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the regularity and characteristics of lithium carbonate-induced thyroid adverse drug reaction(ADR),to provide reference for clinical rational drug use.Methods The case reports of thyroid ADR caused by lithium carbonate in National Center for ADR Monitoring,China were retrieved,and the gender and age of patients,medication reasons,combined medication,dosage and clinical manifestations of thyroid ADR were retrospectively analyzed.Results A total of 237 cases of thyroid ADR caused by lithium carbonate were reported,the ratio of male to female was 1∶1.7,the frequency was higher in the age group of 20 to 29 years,and the proportion of drug use within the range of instruction dosage was 97.8％.According to the statistics of drugs used in combination,the most drugs were for mental disorders,and the time of ADR occurrence was mostly 10 to 30 days after taking the drug.The main clinical manifestations of thyroid ADR were hypothyroidism,goiter and hyperthyroidism.Conclusion Lithium carbonate-induced thyroid ADR mostly occurred at the therapeutic dose,which was related to the patient's gender,age,combined medication and other factors.Clinicians and pharmacists should master the rules and characteristics of thyroid ADR caused by lithium carbonate,timely detect and treat ADR,to provide guarantee for the safety of patients' medication.
