Systematic review of factors influencing olfactory dysfunction in patients with Parkinson's disease
10.3969/j.issn.1673-9701.2025.18.001
- VernacularTitle:帕金森病患者嗅觉障碍影响因素的系统评价
- Author:
Yudan LIU
1
;
Huifang LI
;
Jianchun LI
;
Yaxian ZHAI
;
Jinmei YANG
;
Yunxia SHEN
Author Information
1. 云南中医药大学护理学院,云南 昆明 650500
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Olfactory dysfunction;
Influencing factors;
Systematic review
- From:
China Modern Doctor
2025;63(18):1-4,31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influencing factors of olfactory dysfunction in patients with Parkinson's disease(PD)and conduct a systematic review and Meta-analysis.Methods Articles on factors influencing olfactory dysfunction in PD were retrieved from databases including SinoMed,VIP,China National Knowledge Infrastructure,Wanfang Data Knowledge Service Platform,Web of Science,PubMed,Cochrane,Embase,and MEDLINE.The search period spanned from the inception of each database to November 30,2024.Results A total of 13 articles(with a total sample size of 2465)were included,with a total of 18 influencing factors summarized as two themes:core features and progression factors of PD,and individual background and environmental interaction factors.Meta-analysis showed that age(MD=1.01,95％CI:-0.46-2.49,P=0.18),smoking(OR=0.88,95％CI:0.57-1.37,P=0.57),and constipation(OR=1.22,95％CI:0.38-3.93,P=0.74)were not factors affecting olfactory dysfunction in PD patients.Conclusion Factors influencing olfactory dysfunction in PD are predominantly associated with non-motor symptoms.Intervention strategies targeting non-motor symptoms(such as improving sleep quality,vitamin D supplementation,and early cognitive training)may provide novel approaches for delaying the progression of olfactory dysfunction.
