Mendelian randomization study on free fatty acid receptor 4 and breast cancer
10.3969/j.issn.1673-9701.2025.17.008
- VernacularTitle:游离脂肪酸受体4与乳腺癌关系的孟德尔随机化研究
- Author:
Siyi CHEN
1
;
Hui LI
1
;
Qunying XU
1
;
Jia XIA
1
;
Yunli YE
1
;
Ya LIU
1
Author Information
1. 西南医科大学公共卫生学院,四川泸州 646000
- Publication Type:Journal Article
- Keywords:
Free fatty acid receptor 4;
Breast cancer;
Mendelian randomization;
Co-location analysis
- From:
China Modern Doctor
2025;63(17):29-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the causal relationship between breast cancer and free fatty acid receptor 4(FFAR4)by using two-sample Mendelian randomization.Methods By using Genome-wide Association Studies and expression quantitative trait locus(eQTL)data,single nucleotide polymorphism sites closely related to breast cancer and FFAR4 were extracted.Causal effect values were calculated by using five methods:inverse variance weighting(IVW),MR-Egger,weighted median,simple mode and weighted mode.Cochran Q tests were used to detect heterogeneity,MR-Egger intercept tests and MR-PRESSO tests were used to assess level multiplicity,and the hold-out method was employed for sensitivity analysis to ensure robustness of the results.Additionally,Bayesian co-location analysis was used to evaluate whether FFAR4 expression shares the same causal genetic variant with breast cancer in given genomic region.Results A total of 12 eQTLs closely related to FFAR4 expression levels were included in this study.The results of IVW analysis showed that increased FFAR4 expression levels increased the risk of overall breast cancer,Luminal A,Luminal B/HER2-negative,and HER2-enhanced subtypes of breast cancer.The co-location analysis showed that the posterior probability of FFAR4 expression level and total breast cancer shared causal variation was 0.889.Conclusion There may be a causal relationship between FFAR4 expression and breast cancer.
