Study on the mechanism of Actinidia Chinensis Planch Radix in treating colorectal cancer based on network pharmacology
10.3969/j.issn.1673-9701.2025.17.011
- VernacularTitle:基于网络药理学的藤梨根治疗结直肠癌的机制研究
- Author:
Chenyang MA
1
;
Yu WANG
1
;
Shaohui YANG
1
;
Jun LU
1
Author Information
1. 宁波市医疗中心李惠利医院结直肠外科,浙江宁波 315000
- Publication Type:Journal Article
- Keywords:
Actinidia Chinensis Planch Radix;
Network pharmacology;
Molecular docking;
Colorectal cancer
- From:
China Modern Doctor
2025;63(17):42-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the medicinal mechanism of Actinidia Chinensis Planch Radix(ACPR)in the treatment of colorectal cancer(CRC)by network pharmacology and molecular docking technology.Methods The genes involved in the effects of the main chemical components and disease genes of ACPR were screened from the TCM database and disease database.The main genes were analyzed through protein interaction network analysis,and molecular docking was performed on the main chemical components and key targets.The effects of the drug on tumor cells were measured,and the levels of key proteins in the signaling pathway were detected.Results The primary components of ACPR for treating CRC include quercetin,β-sitosterol,aloe baicalin,and catechin.It targets 144 protein interaction sites and were involved in the protein interaction network,with key genes including AKT1,TP53,MAPK1,JUN,and TNF.The recognition network includes five modules that were involved in various biological processes and signaling pathways.The main components exhibited excellent or good activity when interacting with these targets.At a certain concentration,the drug could inhibit the proliferation,invasion,and migration of colorectal cancer cells and affect the PI3K/AKT signaling pathway.Conclusion ACPR has been used to treat colorectal cancer through multiple pathways and multiple targets,among which the PI3K/AKT signaling pathway may be the mechanism.
