Study of serum MP-DNA load combined with NK cell count to evaluate immune characteristics in children with drug-resistant Mycoplasma pneumoniae pneumonia
10.3969/j.issn.1673-9701.2025.17.007
- VernacularTitle:血清MP-DNA载量联合NK细胞计数评估耐药性肺炎支原体肺炎患儿的免疫特征研究
- Author:
Kaijing ZHANG
1
;
Xiaohui HUANG
;
Xiaojuan YU
;
Junsong CHEN
Author Information
1. 杭州市儿童医院血液科,浙江 杭州 310005
- Publication Type:Journal Article
- Keywords:
NK cells;
MP-DNA;
CD4+T cells;
Mycoplasma pneumoniae pneumonia
- From:
China Modern Doctor
2025;63(17):25-28,37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate immune characteristics of non-responsive macrolide-resistant Mycoplasma pneumoniae pneumonia(MPP)and macrolide-susceptible Mycoplasma pneumoniae pneumonia(MSMPP),and the clinical significance of serum Mycoplasma pneumonia DNA load and NK cell count in the course of disease were evaluated.Methods A total of 120 MPP patients hospitalized at Hangzhou Children's Hospital from August 2022 to August 2023 were selected as subjects,they were divided into MSMPP group(n=36)and macrolide-unresponsive MPP(MUMPP)group(n=84)based on whether they were effective within 72h of using macrolide antibiotics.Compare various indicators levels in the first 6 hours after admission between two groups.Multivariate analysis of variance was used for independent risk factors and receiver operating characteristic(ROC)curve analysis was used for diagnostic performance.Results CD4+T,NK,and lgMP-DNA were independent risk factors for predicting whether MPP patients were MUMPP.The area under ROC curve for CD4+T,NK,lgMP-DNA,NK+CD4+T,lgMP-DNA+CD4+T,and lgMP-DNA+NK were 0.684,0.753,0.728,0.803,0.779,and 0.813,respectively.Conclusion Decreased peripheral blood NK cells and high MP-DNA load are important clinical features of drug-resistant Mycoplasma pneumonia,and combined detection can provide important clinical value for subsequent diagnosis and treatment.
