Research advances in the application of one-step nucleic acid amplification technology in sentinel lymph node biopsy for breast cancer
10.12354/j.issn.1000-8179.2025.20250072
- VernacularTitle:一步核酸扩增技术在乳腺癌前哨淋巴结活检中的应用研究进展
- Author:
Yang XIN
1
;
Sun XIAO
;
Wang YONGSHENG
Author Information
1. 山东第一医科大学(山东省医学科学院)(济南市 250117);山东省肿瘤防治研究院(山东省肿瘤医院)乳腺病中心
- Publication Type:Journal Article
- Keywords:
breast cancer;
one-step nucleic acid amplification(OSNA)technology;
sentinel lymph node(SLN)biopsy;
diagnosis of lymph node metastasis;
neoadjuvant therapy
- From:
Chinese Journal of Clinical Oncology
2025;52(5):259-263
- CountryChina
- Language:Chinese
-
Abstract:
One-step nucleic acid amplification(OSNA)technology is a molecular diagnostic technology that assesses the metastatic status of lymph nodes by detecting the expression level of cytokeratin 19 mRNA in sentinel lymph nodes(SLNs).It is characterized by its rapidity,ac-curacy,semi-quantitative nature,and high reproducibility,thereby providing comprehensive lymph node diagnostic information for clinical physicians.It is of great significance regarding avoiding secondary axillary lymph node dissection(ALND)or excessive ALND.The de-escala-tion treatment pattern for breast cancer is the current therapeutic strategy pursued by surgeons.SLN biopsy(SLNB)can help patients re-ceive more precise and personalized treatment,thereby reducing unnecessary treatment intensity and side effects while ensuring thera-peutic efficacy.This article reviews the application of OSNA detection in SLNB.
