Epidemiological characteristics of children with acute respiratory tract infection and changes of peripheral blood PA,SAA,CRP,and PCT
10.11816/cn.ni.2025-240539
- VernacularTitle:儿童急性呼吸道感染流行病学及外周血PA、SAA、CRP和PCT变化
- Author:
Xiaojun SUN
1
;
Xiaoyan CHANG
;
Yankun WANG
;
Wen MAO
;
Lin WANG
Author Information
1. 青岛大学附属青岛市海慈医院(市中医医院)小儿一科,山东青岛 266032
- Publication Type:Journal Article
- Keywords:
Acute respiratory tract infection in child;
Epidemiology;
Pathogen;
Prealbumin;
Serum amyloid pro-tein A;
C-reactive protein;
Procalcitonin;
Receiver operating characteristic curve;
Diagnostic value
- From:
Chinese Journal of Nosocomiology
2025;35(5):708-712
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the epidemiological characteristics of the children with acute respiratory tract in-fection and analyze the changes of peripheral blood prealbumin(PA),serum amyloid protein A(SAA)and pro-calcitonin(PCT)so as to provide bases for the clinical diagnosis.METHODS A total of 177 children with acute re-spiratory tract infection who were treated in Qingdao Haici Hospital Affiliated to Qingdao University from Nov.2021 to Nov.2023 were assigned as the infection group,meanwhile,195 healthy children who received physical examination were chosen as the healthy group.The distribution of pathogens isolated from the patients of the in-fection group was statistically analyzed.The levels of PA,SAA,CRP and PCT were compared between the two groups.The values of the indexes in diagnosis of the acute respiratory tract infection were analyzed.RESULTS The total positive rate of isolation of pathogens was 31.07％(55/177)among the children with acute respiratory tract infection,and Mycoplasma pneumoniae was the predominant species of pathogen.There was significant difference in the isolation rate of pathogens among the different age groups of children with acute respiratory tract infection(x2=8.270,P=0.041);the children of the preschool age group were dominant.There was significant difference in the isolation rate of pathogens from the children with acute respiratory tract infection among the different sea-sons(x2=9.557,P=0.023);the isolation rates were relatively high in spring and winter.There were significant differences in the levels of serum PA,SAA,CRP and PCT between the infection group and the healthy group(P＜0.05);the CRP level was(13.48±4.25)mg/L in the infection group,(7.85±2.51)mg/L in the healthy group,with the difference value maximum(t=15.724,P＜0.001).The area under the curve(AUC)value of the joint detection of the four indexes was higher than that of the single detection in diagnosis of the acute respiratory tract infection in the children(P＜0.05).CONCLUSIONS M.pneumoniae is dominant among the pathogens isolated from the children with acute respiratory tract infection,the preschool age children are in the majority.The infec-tion is prevalent in spring and winter.The children with the infection show the abnormal expressions of PA,SAA,CRP and PCT,and the joint detection of the four indexes has high value in diagnosis of the infection.
