Methods of antimicrobial stewardship scientific of special antimicrobial agents in a hospital and their application effects
10.11816/cn.ni.2025-248307
- VernacularTitle:某院特殊抗菌药物科学化管理方法及其应用效果
- Author:
Yibin TAN
1
;
Ke LIANG
;
Ying WANG
;
Yingpei ZHANG
Author Information
1. 武汉大学中南医院医院感染管理办公室,湖北武汉 430071
- Publication Type:Journal Article
- Keywords:
Special grade antibiotic;
Scientific management;
Effect;
Antimicrobials use density;
Defined daily do-ses
- From:
Chinese Journal of Nosocomiology
2025;35(5):741-745
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the effect of antimicrobial stewardship scientific(AMS)of antimicrobial agents on special antibiotics so as to provide evidence-based bases for reasonable use of antibiotics.METHODS A retro-spective survey was conducted for the status of use of special antibiotics in Zhongnan Hospital,Wuhan University.The utilization rate of intravenous infusion of antibiotics,antimicrobials use density(AUD)of special grade antibi-otics,defined daily doses(DDDs),etiological submission rate of microorganisms before use of antibiotics and drug resistance rates of major gram-negative bacteria to special grade antibiotics were observed and compared be-fore and after the AMS was carried out.RESULTS There were no significant differences in gender,severity of dis-ease and spectrum of infectious diseases before and after the AMS was carried out.The utilization rate of intrave-nous infusion of antibiotics was(55.64±1.63)％among the hospitalized patients after the AMS was carried out,the AUD of special grade antibiotics was 2.08±0.57,and the DDDs was 2406.53±292.16,showing generally downward trends(P＜0.05).The drug resistance rates of Acinetobacter baumannii strains to cefepime and imi-penem were 89.15％and 90.21％,respectively,showing upward trends(P＜0.05).CONCLUSION The AUD and DDDs of the special grade antibiotics can be remarkably reduced through powerful means such as carrying out AMS,setting up AMS task group for special grade antibiotics,developing guidance documents for scientific use of special antibiotics,taking full advantage of reasonable drug administration surveillance system,implementing closed-loop management of the special antibiotics,and completing early warning mechanisms for bacterial drug re-sistance as well as information construction to boost management.
