Serum growth hormone of children with infectious pneumonia and its association with blood biochemistry and body immunity
10.11816/cn.ni.2025-240475
- VernacularTitle:儿童感染性肺炎血清生长激素及其与血生化和机体免疫的关系
- Author:
Yamin SHANG
1
;
Ying LI
1
;
Xiaojian MA
1
;
Ying DAI
1
;
Qiwei WANG
1
Author Information
1. 河南大学淮河医院儿科,河南开封 475000
- Publication Type:Journal Article
- Keywords:
Infectious pneumonia;
Growth hormone;
Blood biochemistry index;
Humoral immunity;
Cellular im-munity;
Child
- From:
Chinese Journal of Nosocomiology
2025;35(6):900-903
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the serum growth hormone(GH)of the children with infectious pneumonia and analyze its association with blood biochemistry and body immunity.METHODS A total of 211 children with infec-tious pneumonia who were treated in Huaihe Hospital,Henan University from Jan.2023 to Jan.2024 were recrui-ted as the research subjects and were divided into the mild group with 156 cases and the severe group with 55 cases according to the severity of disease.The change of serum GH and the levels of blood biochemical indexes and im-munity indexes were observed and compared between the two groups.Multivariate logistic regression analysis was performed for the influencing factors,receiver operating characteristic(ROC)curves were drawn to analyze the predictive efficiencies.Linear regression analysis was performed to observe the relationship between the infectious pneumonia and the blood biochemistry and body immunity.RESULTS The GH level of the severe group was(18.34±4.33)μg/L,higher than(10.16±2.84)μg/L of the mild group(t=15.853,P＜0.001).There were sig-nificant differences in the blood biochemistry indexes,cellular and humoral immunity indexes between the severe group and the mild group(P＜0.05).The difference values of changes of C-reactive protein(CRP),CD4+and immunoglobulin(Ig)G were the most(t=16.023,87.639,111.957,all P＜0.001).ROC curve analysis showed that the area under the curve(AUC)of CD23+was the highest,with the sensitivity 100.00％,the specificity 98.88％.The result of the linear regression analysis showed that the GH was only positively correlated with the cellular immunity index CD23+(P＜0.05).CONCLUSION The GH level of the children with infectious pneumonia is reduced;the chang of GH level is closely associated with the blood biochemical indexes CRP and the body im-munity of the children.
