Research status and prospects of digestive tract microbiota in gallstone disease
10.3760/cma.j.cn113884-20250219-00052
- VernacularTitle:胆囊结石消化道微生态研究现状及展望
- Author:
Wanyue DAN
1
;
Lihua PENG
1
;
Zikai WANG
1
Author Information
1. 解放军总医院第一医学中心消化内科医学部，北京 100853
- Publication Type:Journal Article
- Keywords:
Cholecystolithiasis;
Digestive tract microbiota;
Gut microbiota;
Microbial mechanism
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(10):797-800
- CountryChina
- Language:Chinese
-
Abstract:
Gallstones are highly prevalent worldwide, with a complex pathogenesis. Symptomatic patients often undergo cholecystectomy, and effective preventive measures are lacking. In recent years, with the deepening of research on digestive tract microbiota, growing evidence has shown that gallstone patients exhibit an imbalance in the digestive tract microbiota, which is involved in bile acid and cholesterol metabolism as well as stone formation through multiple mechanisms. Certain probiotic strains have demonstrated potential in preventing and treating cholesterol gallstones. This article focuses on the current research status of digestive tract microbiota in gallstone disease, including their microbiota composition, potential microbial mechanisms, microecological interventions, and future research directions.
