Research progress on the role of cancer-associated fibroblasts in cholangiocarcinoma
10.3760/cma.j.cn113884-20250319-00091
- VernacularTitle:肿瘤相关成纤维细胞在胆管癌中的作用研究进展
- Author:
Xiaojun SUI
1
;
Lei YANG
;
Dihua LI
;
Dapeng ZHANG
;
Xiangyu SUN
Author Information
1. 天津医科大学附属南开医院肝胆胰外科，天津 300100
- Publication Type:Journal Article
- Keywords:
Cholangiocarcinoma;
Tumor microenvironment;
Cancer-associated fibroblasts;
Heterogeneity
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(10):792-796
- CountryChina
- Language:Chinese
-
Abstract:
Cholangiocarcinoma has an extremely poor prognosis, and the efficacy of existing treatment methods is limited. In the highly desmoplastic tumor microenvironment of cholangiocarcinoma, cancer-associated fibroblasts (CAFs) are the core regulators. Their significant heterogeneity and complex intercellular crosstalk network are not only key factors driving cholangiocarcinoma progression and drug resistance, but also highly promising therapeutic targets. This review focuses on the characteristics of CAFs in cholangiocarcinoma and the key crosstalk mechanisms between CAFs and tumor cells as well as immune cells, and summarizes the research progress and limitations of current therapeutic strategies targeting CAFs.
