Molecular mechanisms and clinical translation of copper metabolism and cuproptosis in hepatocellular carcinoma
10.3760/cma.j.cn113884-20250427-00135
- VernacularTitle:肝细胞癌中铜代谢和铜死亡的分子机制与临床转化
- Author:
Xin ZHANG
1
;
Jianqiao KONG
;
Yun ZHAO
;
Peng ZHANG
;
Zhenghua DING
;
Hengping LI
Author Information
1. 湖北医药学院附属襄阳市第一人民医院普通外科，襄阳 441000
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Cuproptosis;
Copper metabolism;
Molecular mechanism;
Clinical translation
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(10):788-792
- CountryChina
- Language:Chinese
-
Abstract:
Copper death-related factors can modulate mitochondrial function, chemotherapy sensitivity, and reshape the immune microenvironment, playing important roles in the development of hepatocellular carcinoma (HCC). Copper chelators, copper ionophores, and combination with immune checkpoint inhibitors all have significant antitumor effects. Multi-omics analysis reveals that copper death-related genes and cuproptosis-related long non-coding RNAs can serve as prognostic biomarkers and therapeutic targets. This article focused on copper metabolism and copper-induced cell death, reviewing the theoretical foundations of precision therapy for HCC. It delineates the molecular mechanisms by which dysregulated copper homeostasis drives hepatocarcinogenesis and elucidates the translational directions necessary for future research.
