Principle and clinical applications of " Histotripsy" ultrasound tissue fractionation
10.3760/cma.j.cn113884-20241021-00310
- VernacularTitle:"Histotripsy"超声组织碎化术的原理及临床应用
- Author:
Cong ZHOU
1
;
Bo HU
1
;
Yang XU
1
Author Information
1. 复旦大学附属中山医院肝胆肿瘤与肝移植外科，上海 200032
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Histotripsy;
Cavitation cloud;
Clinical trials
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(6):469-473
- CountryChina
- Language:Chinese
-
Abstract:
Histotripsy is a non-invasive ultrasound tissue fractionation technique that utilizes focused ultrasound waves to induce cavitation within tissues, thus generating microbubbles. Subsequently, these microbubbles rapidly expand and collapse, generating mechanical forces that disrupt targeted tissues without the use of heat, with the characteristics of non-thermal and non-ionizing modality. Preclinical studies in animal models have demonstrated the potential of histotripsy in treating both benign and malignant tumors, cardiovascular lesions, thrombi, and hematomas. Preliminary evaluations from randomized controlled clinical trials have also been conducted for liver tumors and benign prostatic hyperplasia. This review summarizes the principles and development of histotripsy, and its clinical applications, particularly in the treatment of liver cancer, and compares them with current clinical ablation technologies.
