Clinical value analysis of Golgi protein 73 in intrahepatic cholangiocellular carcinoma diagnosis
10.3760/cma.j.cn113884-20241114-00337
- VernacularTitle:高尔基体蛋白73对肝内胆管细胞癌诊断的临床价值分析
- Author:
Fengxian WEI
1
;
Tingting ZHOU
;
Yawu ZHANG
;
Xiaodong XU
;
Youcheng ZHANG
Author Information
1. 兰州大学第二医院普通外科，兰州 730030
- Publication Type:Journal Article
- Keywords:
Cholangiocarcinoma;
Golgi protein 73;
Diagnostic value
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(6):458-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically review the clinical value of Golgi protein 73 (GP73) in intrahepatic cholangiocarcinoma (ICC) diagnosis.Methods:Online databases were searched by researchers on CNKI, VIP, Wanfang, PubMed, Embase, and Cochrane library. Clinical studies related to the diagnosis of ICC by GP73 value were included according to inclusion and exclusion criteria. Study data were collected, and then methodological quality was evaluated. Both RevMan 5.3 software and Meta-Disc 1.4 software were used for pooled analysis to investigate the difference of GP73 value between the ICC group and non-ICC group, as well as the diagnostic efficiency of GP73 for ICC.Results:A total of 12 studies comprising 3 723 patients (2 345 males and 1 378 females, aged 18-85 years) were included in the meta-analysis. Among these, 537 cases were definitively diagnosed as ICC, while the remaining 3 186 non-ICC cases included 600 benign liver tumors or healthy controls, 1 795 hepatocellular carcinomas (HCC), and 791 cases of liver cirrhosis. Pooled analysis of serum GP73 levels demonstrated that the ICC group exhibited higher GP73 values than the benign liver tumor/healthy control group [standardized mean difference ( SMD)=2.53, 95% CI: 1.38-3.64], exhibited lower GP73 values than the HCC group ( SMD=-1.69, 95% CI: -2.48--0.89), and both of them reached statistically significant difference (both P<0.001). No statistically significant difference was observed between the ICC and liver cirrhosis groups ( SMD=-0.33, 95% CI: -0.92-0.26, P=0.270). Regarding tissue GP73, the ICC patients showed a significantly higher rate compared to the benign liver tumor [ RR=2.31, 95% CI: 1.83-2.93, P<0.0001], whereas no significant difference was found between the ICC and HCC groups ( RR=0.83, 95% CI: 0.57-1.22, P=0.340). GP73 for ICC diagnosis yielded an area under the ROC curve of 0.87, with a sensitivity of 73% and specificity of 75%. Conclusion:GP73 demonstrates potential utility in ICC diagnosis, but its clinical application may be confounded by concurrent conditions such as liver cirrhosis, which should be identified in clinical practice.
