Research progress on mitophagy in organ ischemia-reperfusion injury
10.3760/cma.j.cn113884-20241209-00370
- VernacularTitle:线粒体自噬在器官缺血再灌注损伤中的研究进展
- Author:
Jingjing YANG
1
;
Longlong WU
1
;
Rong WANG
1
Author Information
1. 山西医科大学附属山西省人民医院消化内科，太原 030012
- Publication Type:Journal Article
- Keywords:
Mitophagy;
Reperfusion injury;
Quality control;
Apoptosis;
Inflammation
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(5):396-400
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion injury (IRI) is a critical factor contributing to damage in multiple organs, involving complex mechanisms such as free radical production, intracellular calcium overload, and excessive activation of inflammatory responses. IRI leads to mitochondrial structural abnormalities and dysfunction, disrupting mitochondrial homeostasis. Mitophagy, a vital mitochondrial quality control mechanism, eliminates damaged mitochondria and reactive oxygen species, which plays a significant role in IRI by reducing the accumulation of harmful intracellular substances and maintaining mitochondrial and cellular homeostasis. This review aims to discuss the research progress of mitochondrial autophagy in organ IRI.
