The impact of preoperative controlling nutritional status score on the prognosis of gallbladder cancer patients with curative resection
10.3760/cma.j.cn113884-20250123-00027
- VernacularTitle:术前控制营养状态评分对胆囊癌患者根治术后预后的影响
- Author:
Xueming ZHANG
1
;
Gong CHENG
1
;
Luoluo WANG
1
Author Information
1. 宁波市医疗中心李惠利医院肝胆胰外科，宁波 315100
- Publication Type:Journal Article
- Keywords:
Gallbladder neoplasms;
Prognosis;
Controlling nutritional status
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(5):346-351
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the impact of preoperative controlling nutritional status (CONUT) score on the prognosis of gallbladder cancer patients with curative resection.Methods:The clinical data of gallbladder cancer patients, treated at Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center Lihuili Hospital from January 2016 to December 2023 were retrospectively analyzed. A total of 184 patients were enrolled in this study, including 84 males and 100 females, aged (67.6±9.5) years. Based on preoperative CONUT score, 184 patients were divided into the low-score group (0-3 points, n=138) and the high-score group (4-12 points, n=46). The clinicopathological features including age, preoperative carbohydrate antigen 125 level, maximum tumor diameter, vascular invasion, postoperative T stage and postoperative hospital length of stay, were compared between two groups. Univariate and multivariate Cox regression analysis were performed to analyze the relationship between preoperative CONUT score and prognosis of gallbladder cancer patients with curative resection. Results:The age, preoperative carbohydrate antigen 125 level, maximum tumor diameter, vascular invasion ratio, postoperative T stage and postoperative hospital length of stay in the high-score group were higher than those in the low-score group, and the differences were statistically significant (all P<0.05). Multivariate Cox regression analysis revealed that high CONUT score (4-12 points) was associated with a higher risk of poor overall survival ( HR=1.932, 95% CI: 1.165-3.203, P=0.011) and poor recurrence-free survival ( HR=1.600, 95% CI: 1.002-2.554, P=0.049). Conclusion:CONUT score (4-12 points) is a risk factor for poor overall survival and recurrence-free survival. Assessment of the CONUT score is an important preoperative consideration.
