Analysis of factors affecting recurrence after liver transplantation for primary biliary cholangitis
10.3760/cma.j.cn113884-20250127-00034
- VernacularTitle:原发性胆汁性胆管炎患者肝移植术后复发的影响因素分析
- Author:
Jing WANG
1
;
Gongming ZHANG
;
Guangming LI
Author Information
1. 首都医科大学附属北京佑安医院麻醉手术中心，北京 100069
- Publication Type:Journal Article
- Keywords:
Cholangitis;
Liver transplantation;
Recurrence;
Root cause analysis
- From:
Chinese Journal of Hepatobiliary Surgery
2025;31(5):321-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the factors influencing recurrence after liver transplantation in patients with primary biliary cholangitis (PBC).Methods:Clinical data of 53 patients with PBC undergoing liver transplantation at the Department of General Surgery, Beijing Youan Hospital, Capital Medical University from August 2006 to January 2024 were retrospectively anaylyzed, including 11 males and 42 females, aged (55.1±7.9) years. Eight (15.1%) of the patients experienced recurrence within five years after liver transplantation. Univariate and multivariate logistic regression analyses were used to identify the factors influencing recurrence after transplantation. The receiver operating characteristic (ROC) curve was used to evaluate the predictive efficacy of each variable for post-transplant recurrence.Results:Univariate logistic regression analysis showed that severe postoperative complications, positive anti-centromere antibodies, and postoperative CD4/CD45<0.4 were associated with recurrence after liver transplantation (all P<0.05). Further multivariate logistic regression analysis revealed that severe postoperative complications ( OR=23.183, 95% CI: 1.667-322.447, P=0.019), postoperative CD4/CD45<0.4 ( OR=9.272, 95% CI: 1.244-69.099, P=0.030), and positive anti-centromere antibodies ( OR=17.106, 95% CI: 1.381-211.878, P=0.027) were associated with a higher risk of recurrence after liver transplantation in patients with PBC. ROC curve analysis showed that the area under the curve for predicting recurrence after liver transplantation based on severe postoperative complications was 0.731 (95% CI: 0.539-0.922, P=0.039), with a sensitivity of 75.0% and a specificity of 71.1%. Conclusion:Severe postoperative complications, CD4/CD45 <0.4, and positive anti-centromere antibodies are risk factors for recurrence after liver transplantation in patients with PBC. Severe postoperative complications showed a good predictive efficacy for recurrence.
