Advances in ITGA7 in glioblastomas

VernacularTitle:ITGA7在胶质母细胞瘤中的研究进展
Author: Hongxi HAN ¹ ; Yuanping SU ; Bo WANG ; Jinwen LI ; Guoqiang YUAN
Author Information

1. 兰州大学第二医院神经外科,甘肃兰州 730000;兰州大学第二医院神经外科实验室,甘肃兰州 730000
Publication Type:Journal Article
Keywords: Glioblastoma; Integrin α7; Cell proliferation; Cell invasion; Signalling pathway
From: Tumor 2024;44(4):422-431
CountryChina
Language:Chinese
Abstract: Glioblastoma(GBM)is a widely occurring and highly invasive central nervous system tumor.Its occurrence and development are closely related to multiple molecular mechanisms,making treatment and prognosis challenging.Integrin α7(ITGA7)is a potential marker for glioblastoma stem cells,and its high expression is associated with poor prognosis in various solid tumor patients.In recent years,research on the pathogenesis of GBM involving ITGA7 has increased.This review summarizes recent studies on the role of ITGA7 in promoting GBM progression,including GBM cell biology,angiogenesis,signaling pathways,and the tumor microenvironment,with the aim of providing references for further understanding the mechanisms of GBM occurrence and development and the exploration of therapeutic targets.