Research progress on the mechanism of ferroptosis-related genes in bladder cancer
10.3781/j.issn.1000-7431.2024.2404-0176
- VernacularTitle:铁死亡相关基因在膀胱癌中的作用机制研究进展
- Author:
Jiajia TANG
1
;
Longmei FAN
;
Tianyu HUANG
;
Mingshun ZUO
;
Yuanjian LIAO
;
Te XU
;
Neng ZHANG
;
Jiangrong ZHANG
Author Information
1. 遵义医科大学附属医院泌尿外科,贵州 遵义 563000;遵义医科大学护理学院,贵州 遵义 563003
- Publication Type:Journal Article
- Keywords:
Erroptosis;
bladder cancer;
mechanism;
prognostic biomarke
- From:
Tumor
2024;44(11):1141-1150
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a form of iron dependent cell death,which is closely related to the progress and prognosis of bladder cancer(BCa).Among them,erroptosis related genes(FRGs)play an important role in the biological effects of BCa,such as participating in regulating the proliferation,migration,metastasis,drug resistance,immune regulation,and therapeutic efficacy of BCa cells.In addition,FRGs are also important biomarkers for predicting the prognosis of tumor patients.However,the specific mechanism of action of FRGs in BCa remains elusive.How to use FRGs to predict the prognosis of BCa and guide the treatment of BCa is still in the exploratory stage.Therefore,exploring the regulatory and predictive role of FRGs in BCa is particularly important for the diagnosis and treatment of BCa.This article aims to systematically elucidate the role of FRGs in the occurrence,development,treatment,and prognosis of BCa.To provide theoretical reference for further exploring the treatment of refractory and drug-resistant BCa patients,and constructing prognostic risk prediction models.
