Evaluation of the efficacy of linaclotide combined with PEG in the bowel preparation for colonoscopy of patients with chronic constipation
10.3969/j.issn.1673-9701.2025.02.021
- VernacularTitle:利那洛肽联合PEG在慢性便秘患者结肠镜检查肠道准备中效果评价
- Author:
Xiaomao GAO
1
;
Yawen LIU
1
;
Qide XU
1
;
Yi HAN
1
;
Zuoyan WU
1
Author Information
1. 北京市第六医院消化科,北京 100007
- Publication Type:Journal Article
- Keywords:
Polyethylene glycol electrolyte powder;
Linaclotide;
Colonoscopy;
Bowel preparation
- From:
China Modern Doctor
2025;63(2):80-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application of linaclotide combined with compound polyethylene glycol electrolyte powder(PEG)in bowel preparation for colonoscopy of patients with chronic constipation.Methods A toltal of 190 patients with chronic constipation who underwent electronic colonoscopy in Beijing NO.6 Hospital from January to October 2023 were selected as the objects.The patients were divide into linaclotide group(n=63),3L PEG group(n=64),and 4L PEG group(n=63)by random number table method.The application effects of three groups were compared.Results Boston bowel preparation scale score was higher than 3L PEG and 4L PEG groups,there were significant difference among groups(P＜0.05).The qualified rate of patients in linaclotide group was better than that of 3L PEG group and 4L PEG group,and the qualified rate of patients in 4L PEG group was better than that of 3L PEG group,there were significant difference among groups(P＜0.05).Conclusion Linaclotide combined with PEG can not only improve the intestinal cleaning quality of patients with constipation,but also do not increase the adverse reactions of patients.
