Clinical effects of Buzhong Yiqi Decoction combined with 3HRZE/9HRE anti-tuberculosis chemotherapy regimen on patients with intestinal tuberculosis
10.3969/j.issn.1001-1528.2025.01.014
- VernacularTitle:补中益气汤联合3HRZE/9HRE抗结核化疗方案对肠结核患者的临床疗效
- Author:
Ling LIU
1
;
Feng-ying JING
;
Xiao-xia SHAO
Author Information
1. 陕西省结核病防治院/陕西省第五人民医院内科,陕西西安 710100
- Publication Type:Journal Article
- Keywords:
Buzhong Yiqi Decoction;
3HRZE/9HRE anti-tuberculosis chemotherapy regimen;
intestinal tuberculosis;
gastrointestinal functions;
Th17/Treg immune balance
- From:
Chinese Traditional Patent Medicine
2025;47(1):91-95
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Buzhong Yiqi Decoction combined with 3HRZE/9HRE anti-tuberculosis chemotherapy regimen on patients with intestinal tuberculosis.METHODS Eighty patients were randomly assigned into control group(40 cases)for administration of 3HRZE/9HRE anti-tuberculosis chemotherapy regimen,and observation group(40 cases)for administration of both Buzhong Yiqi Decoction and 3HRZE/9HRE anti-tuberculosis chemotherapy regimen.The changes in clinical effects,TCM syndrome score,intestinal mucosal barrier function indices(lactulose,mannitol,L/M,DAO),gastrointestinal function hormones(MTL,CCK,GAS,VIP),Th17,Treg,Th17/Treg and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05),along with lower incidence of adverse reactions(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome score,lactulose,L/M,DAO,CCK,GAS,VIP,Th17,Th17/Treg(P＜0.05),and increased MTL,Treg(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients with intestinal tuberculosis,Buzhong Yiqi Decoction combined with 3HRZE/9HRE anti-tuberculosis chemotherapy regimen can safely and effectively alleviate clinical symptoms,enhance gastrointestinal functions,and improve Th17/Treg immune balance.
