Analysis of the efficacy and influencing factors of radiotherapy after keloid surgery
10.3969/j.issn.1673-9701.2025.02.003
- VernacularTitle:瘢痕疙瘩术后放疗的疗效及影响因素分析
- Author:
Xiaoxiao ZHOU
1
;
Dongmei WU
1
;
Yulong TIAN
1
;
Qingyuan DUAN
1
;
Minjie LI
1
Author Information
1. 郑州大学第五附属医院放疗科,河南郑州 450052
- Publication Type:Journal Article
- Keywords:
Keloid;
Radiotherapy;
Recurrence;
Efficacy
- From:
China Modern Doctor
2025;63(2):9-11,23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of hypofractionated radiotherapy at different time intervals after surgery for keloid,and to analyze the factors affecting the efficacy.Methods A total of 76 patients who underwent 20 Gy/5 postoperative radiotherapy regimen in the Fifth Affiliated Hospital of Zhengzhou University from January 2021 to June 2023 were selected as study subjects,and a total of 100 keloids were divided into effective group(n=79)and recurrence group(n=21).Regular follow-up and record of the patients after radiotherapy treatment effect and adverse effects,and multivariate Logistic was used to analyze factors of recurrence in keloid patients.Results Multivariate Logistic regression analysis found that postoperative radiotherapy time and scar incision length were related to recurrence after treatment,radiotherapy within 7h of surgery was an independent risk factor for recurrence after treatment(OR＞1,P=0.022),and scar incision≤5cm was an independent protective factor for recurrence after treatment(OR＜1,P=0.028).Conclusion Surgical excision combined with hypofractionated radiotherapy is one of the effective measures to prevent and treat keloid recurrence,though keloids on the trunk may need more effective treatment options.The recurrence rate of radiotherapy initiated 7-48h after surgery is relatively the lowest,and it is worthy of clinical promotion and application.
