Morphological and hemodynamic parameters of CT angiography for predicting recurrence of intracranial aneurysms after endovascular embolization
10.13929/j.issn.1003-3289.2025.01.003
- VernacularTitle:CT血管成像形态学及血流动力学参数预测颅内动脉瘤经血管内栓塞治疗后复发
- Author:
Xinran WANG
1
;
Bin HU
1
;
Zhao SHI
1
;
Longjiang ZHANG
1
Author Information
1. 南京大学医学院附属金陵医院(东部战区总医院)放射科,江苏南京 210002
- Publication Type:Journal Article
- Keywords:
intracranial aneurysm;
hemodynamics;
recurrence;
angiography
- From:
Chinese Journal of Medical Imaging Technology
2025;41(1):9-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of morphological and hemodynamic parameters of CT angiography(CTA)for predicting recurrence of intracranial aneurysms(IA)after endovascular embolization.Methods Totally 205 patients with ruptured IA who underwent endovascular embolization were retrospectively collected and divided into recurrence group(n=35)and non-recurrence group(n=170)according to follow-up results after embolization.The morphological and hemodynamic parameters of IA in CTA before treatment were compared between groups.Variance inflation factor(VIF)was used to explore whether there was collinearity between morphological and hemodynamic parameters,and those without collinearity were included in univariate and multivariate logistic regression analysis to screen predictors of recurrence of IA after endovascular embolization.Two prediction models were constructed based on morphological parameters(model 1)and combination with hemodynamic parameters(model 2).Receiver operating characteristic(ROC)curve was plotted,and the area under the curve(AUC)was calculated to evaluate the predictive efficacy of models.Results The maximum diameter,aneurysm neck width,maximum height,maximum vertical height and size ratio(SR)of IA in recurrence group were all higher than those in non-recurrence group(all P＜0.05),while gradient oscillatory number(GON)in recurrence group was lower than that in non-recurrence group(P＜0.05).The neck width,SR,pressure at IA neck plane,intra-aneurysm time-averaged wall shear stress(TAWSS),oscillatory shear index(OSI)and GON had no significant collinearity(all VIF＜10),among which the neck width,SR and TAWSS were all independent predictors(all P＜0.05).AUC of model 1 and model 2 for predicting recurrence of IA after endovascular embolization was 0.668 and 0.723,respectively,which of model 2 was higher than which of model 1(integrated discrimination improvement index was 0.055,P=0.025).Conclusion CTA morphological parameters combined with hemodynamic parameters of IA could be used to predict its recurrence after endovascular embolization.
