Exploring medication patterns in cognitive impairment in Parkinson's disease based on data mining
10.3969/j.issn.1673-9701.2025.02.019
- VernacularTitle:基于数据挖掘探析帕金森病认知障碍的用药规律
- Author:
Yunxian BAI
1
;
Huihe ZHANG
;
Jianping HUANG
;
Lingzhi WEN
;
Xiaoxuan HUANG
Author Information
1. 浙江中医药大学附属温州市中医院神经内科,浙江温州 325000
- Publication Type:Journal Article
- Keywords:
Cognitive impairment in Parkinson's disease;
Benefiting the essence and filling the marrow;
Data mining
- From:
China Modern Doctor
2025;63(2):72-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the pattern of group medication in Parkinson's disease cognitive disorders based on data mining.Methods The famous TCM experience and effective clinical treatment of cognitive impairment in the treatment of Parkinson's disease were retrieved in databases of CNKI,Wanfang and Weipu,from the founding of the databases to August 2024.Medication rules were analyzed.Results A total of 60 Chinese prescriptions were included,including 120 traditional Chinese medicines.High-frequency drugs for the treatment of cognitive impairment in Parkinson's disease included Radix Rehmanniae Praeparata,Radix Paeoniae Alba,Rhizoma Gastrodiae Praeparata,Fructus Lycii,Herba Cistanches,Acorus Calamus and others.The flavour of the medicine were mainly sweet,bitter and pungent,the nature of the medicine was mainly warm,cold and calm and the meridians of the medicine were mainly liver,kidney and heart.Radix Rehmanniae Praeparata-Comu Cervi Pantotrichum,Rhizoma Gastrodiae Praeparata-Hooker's Tree,Radix Rehmanniae Praeparata-Cistanches are the commonly used pairs;Lycium barbarum-Cornus officinalis-Radix Rehmanniae Praeparata,Radix Rehmanniae Praeparata-Radix Angelicae Sinensis-Radix Paeoniae Alba were commonly used combination.Cluster analysis yielded 5 broad categories.Conclusion The primary pharmacological agents employed in traditional Chinese medicine to address cognitive impairment associated with Parkinson's disease emphasize the replenishment of essence and nourishing the marrow.These agents are complemented by nootropic substances that facilitate bodily openness,promote liver health,alleviate wind,resolve phlegm,and invigorate blood circulation and meridian pathways,worth of clinical promotion and application.
