High-resolution MRI for predicting prognosis of esophageal squamous cell carcinoma after definitive chemoradiotherapy
10.13929/j.issn.1003-3289.2025.01.020
- VernacularTitle:高分辨MRI预测食管鳞癌经根治性放化疗后预后
- Author:
Linlin WANG
1
;
Shuo YAN
1
;
Xiaoting LI
1
;
Yanjie SHI
1
;
Yingshi SUN
1
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所医学影像科恶性肿瘤发病机制及转化研究教育部重点实验室,北京 100142
- Publication Type:Journal Article
- Keywords:
esophageal squamous cell carcinoma;
magnetic resonance imaging;
chemoradiotherapy;
disease progression
- From:
Chinese Journal of Medical Imaging Technology
2025;41(1):94-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of Cox proportional hazards regression model constructed based on high-resolution MRI for predicting the risk of esophageal squamous cell carcinoma(ESCC)progression after definitive chemoradiotherapy(dCRT).Methods Thirty ESCC patients who underwent dCRT were retrospectively enrolled.Quantitative and qualitative indicators of primary tumor and imaging-defined metastatic lymph nodes were analyzed based on pre-treatment high-resolution M RI.The progression-free survival(PFS)of patients were recorded.A Cox proportional hazards regression model was established to predict the risk of tumor progression based on MRI indices,and the risks of tumor progression were stratified into high and low according to the median prediction.PFS rates were compared between patients with high or low risk of tumor progression.Results Tumor thickness(HR[95％CI]=1.210[1.025,1.429],P=0.024),relationship between the tumor and aorta(HR[95％CI]=4.275[1.064,17.168],P=0.041)and lymph node signal change rate on delayed phase pre-treatment MRI(HR[95％CI]=0.049[0.007,0.362],P=0.003)were all independent factors for predicting PFS.Based on Cox proportional hazards regression model and its predicted value,PFS rate in high risk patients was lower than that in low risk patients(P＜0.05).Conclusion High-resolution MRI could be used to predict prognosis of ESCC after dCRT.
