Intravoxel incoherent motion histogram parameters for predicting perineural invasion of rectal cancer
10.13929/j.issn.1003-3289.2025.01.021
- VernacularTitle:体素内不相干运动直方图参数预测直肠癌神经周围浸润
- Author:
Changjiang ZHANG
1
;
Junfan CHEN
1
;
Doudou HUANG
1
;
Wenli JIANG
1
;
Yindeng LUO
1
Author Information
1. 重庆医科大学附属第二医院放射科,重庆 400010
- Publication Type:Journal Article
- Keywords:
rectal neoplasms;
magnetic resonance imaging;
intravoxel incoherent motion
- From:
Chinese Journal of Medical Imaging Technology
2025;41(1):99-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of intravoxel incoherent motion(IVIM)histogram parameters for predicting perineural invasion(PNI)of rectal cancer.Methods Fifty-five patients with rectal cancer were retrospectively enrolled and divided into positive group(n=23)and negative group(n=32)according to PNI or not.Histogram parameters of apparent diffusion coefficient(ADC),perfusion fraction(f),true diffusion coefficient(D)and pseudo diffusion coefficient(D*)were obtained based on MR IVIM images,including the mean,skewness,kurtosis,entropy,as well as the 25th,50th and 75th percentiles(25th,50th,75th).The above IVIM histogram parameters were compared between groups,and those with significant difference were included in binary stepwise logistic regression analysis to screen independent factors for predicting PNI status of rectal cancer.Then a combined parameter model was established.Receiver operating characteristic curve was drawn,and the area under the curve(AUC)was calculated to evaluate the efficacy of IVIM histogram parameters and combined parameter model for predicting PNI of rectal cancer.Results ADCmean,ADC25th,ADC50th,ADC75th,fmean,f25th,f50th,f75th and Dentropy in positive group were all lower than those in negative group(all P＜0.05).AUC of the above parameters for predicting PNI of rectal cancer was 0.693,0.665,0.701,0.675,0.831,0.847,0.835,0.722 and 0.785,respectively.The sensitivity,specificity and AUC of combined parameter model based on f25th and Dentropy for predicting PNI of rectal cancer was 95.65％,65.63％and 0.897,respectively.Conclusion IVIM histogram parameters could be used to predict PNI of rectal cancer effectively.
