Neuroimaging features of insomnia disorder and therapeutic effect of repeated transcranial magnetic stimulation
10.13929/j.issn.1003-3289.2025.01.009
- VernacularTitle:失眠障碍神经影像学特征及重复经颅磁刺激治疗效果
- Author:
Zeqi YUAN
1
;
Zhengnan ZHANG
1
;
Huixiao WANG
1
;
Haiqing YANG
1
;
Pingyong FENG
1
;
Lixia ZHOU
1
;
Jiping YANG
1
;
Duo GAO
1
Author Information
1. 河北医科大学第二医院医学影像科,河北石家庄 050000
- Publication Type:Journal Article
- Keywords:
sleep disorders,circadian rhythm;
magnetic resonance imaging;
amplitude of low-frequency fluctuations;
regional homogeneity;
functional connectivity;
transcranial magnetic stimulation;
prospective studies
- From:
Chinese Journal of Medical Imaging Technology
2025;41(1):40-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe brain function changes in insomnia disorder(ID)patients and therapeutic effect of repeated transcranial magnetic stimulation(rTMS)based on resting-state functional MRI(rs-fMRI).Methods Totally 37 patients with ID(ID group)and 20 healthy subjects(control group)were prospectively enrolled.The scores of sleep condition and psychological state scales were compared between groups,also within ID group before and after rTMS treatment.Brain regions with amplitude of low frequency fluctuations(ALFF)and regional homogeneity(ReHo)being significantly different between groups were evaluated based on brain rs-fMRI,and voxel-based resting-state functional connectivity(FC)analysis was performed in the above regions and the predefined regions of interest.Results Before treatment,Pittsburgh sleep quality index(PSQI),insomnia severity index(ISI),Epworth sleepiness score(ESS),Beck depression inventory(BDI)score and Beck anxiety inventory(BAI)score in ID group were all higher than those in control group(all P＜0.05).ALFF values and ReHo of the right median cingulate and paracingulate gyrus(Cingulum_Mid_R)were lower in ID group than those in control group(all FWE correctedP＜0.05).FC between Cingulum_Mid_R and the left anterior cingulate gyrus and cingulate gyrus(Cingulum_Ant_L)decreased,so did that between the left hippocampus(Hippocampus_L)and the right frontal gyrus(Frontal_Mid_R)(all FWE corrected P＜0.05).After rTMS,PSQI,ISI and ESS scores of ID patients decreased compared to those before treatment(all P＜0.05),but no significant change of the above neuroimaging indicators was detected(all FWE corrected P＞0.05).Conclusion ID caused synchronous decrease of Cingulum_Mid_R ALFF value and ReHo,as well as weakened FC between frontal cingulate gyrus and frontal with lobe limbic system.rTMS could improve sleep and mental state of ID patients,but its impact on neuroimaging needed further investigation.
