Early wake-up effect of ganglioside sodium combined with hyperbaric oxygen on patients in coma due to craniocerebral injury
10.3760/cma.j.cn311847-20200228-00073
- VernacularTitle:神经节苷脂钠联合高压氧在颅脑损伤昏迷早期促醒中的效果观察
- Author:
Xin XU
1
;
Jiahui ZHANG
;
Liao WU
;
Guihua NI
Author Information
1. 223300 江苏省淮安，南京医科大学附属淮安第一医院神经内科
- Publication Type:Journal Article
- Keywords:
Ganglioside sodium;
Hyperbaric oxygen;
Severe craniocerebral injury;
Wake-up effect;
Coma
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(5):527-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the early wake-up effect of ganglioside sodium combined with hyperbaric oxygen on patients in coma due to severe head injury.Methods:After receiving the informed consent from their families, 90 patients in persistent coma after surgery for severe craniocerebral injury were divided into 3 groups by the random number table method: hyperbaric oxygen group (30 cases), ganglioside sodium group (30 cases), and combined medication group (30 cases). The inflammatory indexes including the levels of superoxide dismutase (SOD), interleukin 8 (IL-8), and tumor necrosis factor-α (TNF-α) before and after treatment in the three groups were observed, as well as their Glasgow coma scale (GCS) scores, efficacy, adverse reactions, and awake rate after treatment.Results:After 1 month of treatment, the awake rate (86.7%) and GCS score (12.5±2.1) of the combined medication group were higher than those of the hyperbaric oxygen group (48.39%, 9.5±1.7) and the ganglioside sodium group (53.33%, 8.6±1.8), while its awake time was shorter than those of the hyperbaric oxygen group and the ganglioside sodium group, and the differences were statistically significant ( P<0.05). There were no significant differences in the incidence of arrhythmia, vomiting, hematochezia, diarrhea, allergic reaction, liver enzyme abnormalities, and the total adverse reactions in the three groups ( P>0.05). After three months of treatment, the recovery rate (53.33%) of the combined medication group was higher than those of the hyperbaric oxygen group (26.67%) and the ganglioside group(23.33%), and its mortality (6.67%) was lower than those of the hyperbaric oxygen group (40.00%) and the ganglioside sodium group (40.00%), and the differences were statistically significant ( P<0.05). There was no significant difference in the levels of IL-8, TNF-α and SOD between the three groups before treatment ( P>0.05). After one course of treatment, the levels of IL-8 and TNF-α in the combined medication group were lower than those in the hyperbaric oxygen group and ganglioside sodium group, while its SOD was higher than those in the hypoxic group and the ganglioside sodium group, and the differences were statistically significant ( P<0.05). Conclusion:Ganglioside sodium combined with hyperbaric oxygen has a significant early wake-up effect on patients in coma due to severe craniocerebral injury. It can reduce the inflammatory response level and has a high safety.
