Protective effect of hyperbaric oxygen as an auxiliary treatment on cranial nerve in nasopharyngeal carcinoma patients with radioactive encephalopathy
10.3760/cma.j.cn311847-20191023-00273
- VernacularTitle:高压氧辅助治疗对鼻咽癌患者放射性脑病的脑神经保护作用研究
- Author:
Junkai XU
1
;
Yunhui ZHAO
;
Yiping HUANG
;
Xuejiao HUANG
;
Qisong CHEN
Author Information
1. 351100 福建省莆田，莆田学院附属医院放疗科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Nasopharyngeal carcinoma;
Radiation encephalopathy;
Cerebral nerve protection
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2020;27(5):531-534
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the protective effect of hyperbaric oxygen as an auxiliary treatment on cranial nerve in nasopharyngeal carcinoma patients with radioactive encephalopathy.Methods:A total of 96 patients with nasopharyngeal carcinoma admitted to the Affiliated Hospital (Group) of Putian University from January 2015 to June 2018 were selected as the retrospective study objects and divided into control group ( n=48) and observation group ( n=48). The control group was treated with the conventional chemoradiotherapy (the radiotherapy adopted intensity modulated radiation), while the observation group received hyperbaric oxygen as an auxiliary treatment on the basis of the treatment of the control group. The partial pressure oxygen (PaO 2) in blood, serum neuro-related substances, cognitive function, and the occurrences of radiation encephalopathy and death were compared between the two groups. Results:After treatment, the levels of PaO 2, serum neuron-specific enolase (NSE), and S100β in both groups were significantly improved ( P<0.05). In addition, PaO 2 in the observation group was higher than that in the control group, and the serum levels of NSE [(25.64±1.82)ng/L] and S100β [(1.94±0.21)ng/L] in the observation group were significantly lower than those in the control group [(27.88±1.55) ng/L, (2.23±0.16) ng/L), with statistically significant differences ( P<0.05). The mini-mental state examination (MMSE) score and modified Barthel index (MBI) score of cognitive function in the observation group were significantly increased, and the improvements were better than those in the control group ( P<0.05). After one-year follow-up, the incidence of radiation encephalopathy in the observation group was 10.42%, which was significantly lower than that in the control group ( P<0.05). Comparing the survival rate in the observation group (93.75%) with that of the control group (85.42%), there was no statistically significant difference ( P>0.05). Conclusion:Hyperbaric oxygen as an auxiliary treatment can lower the incidence of radiation encephalopathy by increasing oxygen supply to brain, reducing nerve injury, and improving cognitive function, which is of great significance to improve prognosis.
