Summary of Professor GAO Xiangfu's Experience in Treating Chronic Kidney Disease with Drug Pairs
10.16466/j.issn1005-5509.2025.01.008
- VernacularTitle:高祥福教授运用药对治疗慢性肾脏病经验总结
- Author:
Zhehao HUANG
1
;
Zhouqi CHEN
;
Jiawen QIAN
Author Information
1. 浙江中医药大学第一临床医学院 杭州 310053
- Publication Type:Journal Article
- Keywords:
chronic kidney disease;
hidden toxin;
drug pairs;
triangular drugs;
medical records;
GAO Xiangfu;
clinical experience
- From:
Journal of Zhejiang Chinese Medical University
2025;49(1):46-53
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To summarize Professor GAO Xiangfu's experience in treating chronic kidney disease with drug pairs and triangular drugs.[Methods]By following the Professor during clinical consultations,organizing medical cases and reviewing literature,this paper summarized Professor GAO's understanding of the pathogenesis and the characteristics of diagnosis and treatment of chronic kidney disease,and the composition,compatibility principles,clinical applications,common doses,and compatibility significance of Professor GAO's commonly using drug pairs and triangular drugs in treatment chronic kidney disease and a medical case was attached for evidence.[Results]Professor GAO believes that the pathological condition of chronic kidney disease is deficient in origin and excess in superficiality.The core pathogenesis of disease progression is characterized by"vital Qi is deficient and toxins are hiding,essence and blood are leaking,vital Qi is attenuating and toxins are enhancing".The deficiency of vital Qi is mainly manifested as deficiency of the spleen and kidney,while the hidden toxins are mainly turbid toxins,blood stasis toxins and heat toxins.In treatment,the priorities should be put on the origin and the superficiality of the pathogenesis,and a case being acute or chronic should be distinguished first,following the principle of treatment that"treating acute cases as the emerging diseases and treating the chronic cases as the primary disease".For acute progressive cases of this disease,drug pairs for eliminating hidden toxins are commonly combined with classic prescriptions.For chronic protracted cases,drug pairs are often used to formulate prescriptions directly.Particularly,Professor GAO commonly uses"Astragalus membranaceus-Angelica sinensis""Astragalus membranaceus-Atractylodes macrocephala"and"Astragalus membranaceus-Cimicifuga foetida-Bupleurum chinense"are used to tonify spleen Qi and invigorate middle-Jiao;he uses"Radix rehmanniae-Dioscorea opposita-Poria cocos""Herba epimedii-Cistanche deserticola"to nourish kidney Yin and tonify kidney Yang,uses"Herba plantaginis-Rheum officinale""Salvia miltiorrhiza-Centella asiatica"to eliminate turbid and blood stasis,and clear stagnated heat,and uses"Rhizoma imperatae-Agrimonia pilosa""Rosa laevigata-Semen euryales"to calm the blood collaterals and control essence.In the attached medical case,a patient with chronic kidney disease was treated with a main formula consisting of five drug pairs including"Astragalus membranaceus-Angelica sinensis""Radix rehmanniae-Dioscorea opposita-Poria cocos""Herba plantaginis-Rheum officinale""Salvia miltiorrhiza-Centella asiatica"and"Rhizoma imperatae-Agrimonia pilosa",which was adjusted according to the symptoms,and ultimately achieved good results.[Conclusion]Professor GAO's approach to treating chronic kidney disease with drug pairs and triangular drugs is characterized by mild medication,hierarchical compatibility and remarkable efficacy,which is worth summarizing and promoting.
