Research progress in immunotherapy for colorectal cancer liver metastases

VernacularTitle:结直肠癌肝转移免疫治疗研究进展
Author: Wang XIN ¹ ; Qiao RONG ; Kong SHENGNAN ; Yang RUIXIA ; Hei YUE ; Qin HONGYAN ; Chen YAN
Author Information

1. 西安医学院(西安市 710000);空军军医大学西京医院肿瘤科
Publication Type:Journal Article
Keywords: colorectal cancer(CRC); liver metastasis; immunotherapy; DNA mismatch repair defects
From: Chinese Journal of Clinical Oncology 2024;51(24):1273-1279
CountryChina
Language:Chinese
Abstract: Liver metastasis is a key factor impacting the treatment outcomes and survival prognoses of patients with colorectal cancer(CRC).In recent years,immunotherapy has demonstrated revolutionary potential in the treatment of a wide range of solid tumors by strengthen-ing the host's antitumor immune response and has become a mainstream option for the treatment of metastatic or recurrent solid tumors.Immune checkpoint inhibitor-based immunotherapy,in particular,has shown promising advances in safety and efficacy in CRC treatment,especially for deficient mismatch repair(dMMR)CRC.Despite these advances,patients with liver metastases have not seen any improvements in their survival prognoses.In this article,we comprehensively review immunotherapeutic strategies for treating liver metastases from CRC,discuss the efficacy of each strategy,and provide an in-depth discussion of prospective future directions.