Research progress on cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis
10.12354/j.issn.1000-8179.2024.20241331
- VernacularTitle:免疫检查点抑制剂相关心肌炎的心血管磁共振研究进展
- Author:
Qi HANXIONG
1
;
Zhang DAN
1
;
Ye ZHAOXIANG
1
Author Information
1. 天津医科大学肿瘤医院放射科,国家恶性肿瘤临床医学研究中心,天津市恶性肿瘤临床医学研究中心,药物成药性评价与系统转化全国重点实验室,天津市"肿瘤防治"重点实验室(天津市 300060)
- Publication Type:Journal Article
- Keywords:
immune checkpoint inhibitors(ICIs);
myocarditis;
cardiovascular magnetic resonance(CMR)
- From:
Chinese Journal of Clinical Oncology
2024;51(24):1280-1284
- CountryChina
- Language:Chinese
-
Abstract:
Although immune checkpoint inhibitors(ICIs)enhance the immune system's capacity to destroy tumor cells,they can also induce a range of toxic responses that lead to cardiovascular damage.Among these adverse effects,ICI-associated myocarditis(ICI-M)has the highest morbidity and mortality rates,presenting a significant challenge in clinical practice.Cardiovascular magnetic resonance(CMR)is re-garded as the"gold standard"for noninvasive assessment of cardiac structure,function,and tissue characteristics.While this imaging tech-nique has advanced rapidly in recent years,with both domestic and international guidelines recognizing it as a crucial tool for evaluating ICI-M.This article provides a comprehensive overview of the pathological mechanisms underlying ICI-M,its diagnostic criteria,and the latest re-search developments in CMR and its clinical applications;it also discusses the most recent domestic and international guidelines and re-search findings.
