Research progress on the mechanisms of isocitrate dehydrogenase mutations in tumor development
10.12354/j.issn.1000-8179.2024.20241292
- VernacularTitle:IDH突变介导肿瘤发生发展的作用机制研究进展
- Author:
Wang ZIJUN
1
;
Tao WANRU
;
Bao LEILEI
Author Information
1. 江西中医药大学(南昌市 330004)
- Publication Type:Journal Article
- Keywords:
IDH mutation;
metabolic reprogramming;
epigenetics;
immune microenvironment
- From:
Chinese Journal of Clinical Oncology
2024;51(23):1227-1231
- CountryChina
- Language:Chinese
-
Abstract:
Isocitrate dehydrogenase(IDH)mutation occurs frequently in glioma,cholangiocarcinoma,acute myeloid leukemia,chondro sar-coma and other tumors,and it's a potential target for cancer treatment.The novel cancer metabolite 2-hydroxyglutaric acid(2-HG)pro-duced after mutation has become an important marker for cancer treatment and prognosis evaluation.IDH mutation accurately down-regu-lates various biological processes such as glucose metabolism,lipid metabolism and amino acid metabolism in tumors.In addition,IDH mutation also affects the balance of immune microenvironment and epigenetic regulation,and its mechanism of action in the occurrence and development of cancer needs to be further explored and studied.This article reviews the mechanism of action and potential therapeut-ic strategies of IDH mutation in the development of tumors,aiming to provide novel therapeutic options for patients with IDH mutation.
