CT manifestations of pulmonary graft-versus-host disease after allogenic hematopoietic stem cell transplantation in children
10.13929/j.issn.1003-3289.2024.12.010
- VernacularTitle:儿童异基因造血干细胞移植术后肺移植物抗宿主病CT表现
- Author:
Yuzhu SHI
1
;
Lianbo LI
1
;
Li LI
1
;
Kai WANG
1
;
Bofeng LIU
1
;
Man CHEN
1
Author Information
1. 河北燕达陆道培医院放射科,河北廊坊 065201
- Publication Type:Journal Article
- Keywords:
child;
hematopoietic stem cell transplantation;
lung;
graft vs host disease;
tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2024;40(12):1851-1855
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate CT manifestations of pulmonary graft-versus-host disease(GVHD)after allogeneic hematopoietic stem cell transplantation(allo-HSCT)in children.Methods A total of 311 children with pulmonary GVHD who underwent allo-HSCT were retrospectively analyzed.According to the onset time of pulmonary GVHD within 100 days after allo-HSCT or not,the patients were divided into acute group(n=82)and chronic group(n=229).Chest CT manifestations were observed and compared between groups,and children survival after treatments were recorded an d compared between groups.Results The main CT manifestations of pulmonary GVHD after allo-HSCT in children included ground glass opacity(GGO)(82/311,26.37％),air trapping(78/311,25.08％),thickening bronchial wall(32/311,10.29％),bronchiectasis(28/311,9.00％),pleural effusion(43/311,13.83％),thickening interlobular septum(43/311,13.83％),thickening pleura(41/311,13.18％)and thoracic air leak syndrome(41/311,13.18％).The proportion of localized GGO,diffuse GGO,pleural effusion and thickening interlobular septum in acute group were all higher,while of air trapping and bronchiectasis were both lower than those in chronic group(all P＜0.05).No significant difference of other menifeatations was found between groups(all P＞0.05).After treatments,85 cases died,and the mortality rate was 27.33％(85/311),which in acute group(30/82,36.59％)was higher than in chronic group(55/229,24.02％)(x2=4.802,P=0.031).Conclusion CT manifestations of pulmonary GVHD after allo-HSCT in children had certain characteristics.
