Roles of Prostaglandin E Receptor in Tumor Microenvi-ronment and Its Potential Application in Cancer Therapy
10.11735/j.issn.1004-0242.2025.02.A011
- VernacularTitle:前列腺素E受体在肿瘤微环境中的作用及其在肿瘤治疗应用中的研究进展
- Author:
Xiaoyu WU
1
;
Jiong DENG
;
Tong WANG
Author Information
1. 山东第二医科大学基础医学院,山东潍坊 261053
- Publication Type:Journal Article
- Keywords:
prostaglandin E receptor;
prostaglandin E2;
tumor microenvironment;
cancer therapy
- From:
China Cancer
2025;34(2):159-164
- CountryChina
- Language:Chinese
-
Abstract:
Prostaglandin E2(PGE2)regulates a variety of cells in tumor microenvironment(TME)and plays an important role in tumor growth,metastasis and immunity.PGE2 activates different downstream signaling pathways through its key receptor prostaglandin E receptor(EP4),regulating inflammation,immune cell function and angiogenesis to promote or inhibit tumor development.EP4 shows potential application values in adjuvant chemotherapy and immunotherapy as an emerging anti-tumor target.However,future studies on the roles of EP4 in tumor microenvironment,develo-pment of safer and more effective EP4 drugs,and its application in personalized immunotherapy are needed.
